Eugene is home to the University of Oregon. The city is also noted for its natural beauty, activist political leanings, alternative lifestyles, recreation opportunities (especially bicycling, rafting, and kayaking), and arts focus. Eugene's motto is "The World's Greatest City of the Arts and Outdoors." It is also referred to as "The Emerald Empire," "The Emerald City," "The People's Republic of Eugene," and "Track Town, USA" or "The Track Capital of the World." The Nike corporation had its beginnings in Eugene.

Eugene is named after its founder, Eugene Franklin Skinner. In 1846, Skinner erected the first cabin in the area. It was used as a trading post and was registered as an official post office on January 8, 1850. At this time the location was known as Skinner's Mudhole. Skinner founded Eugene in 1862 and later ran a ferry service across the Willamette River where the Ferry Street Bridge now stands.

The first major educational institution in the area was Columbia College. It was founded in the same general area as, and a few years earlier than, the University of Oregon. It fell victim to two different major fires over four years, and after the second fire it was decided not to rebuild again. The part of south Eugene known as as College Hill was the former location of Columbia College. There is no college there today.

The town raised the initial funding to start a public University, which later became the University of Oregon, with the hope of turning the small town into a cultural center of learning. In 1872, the Legislative Assembly passed a bill ratifying the University. The nearby town of Albany was Eugene's biggest competitor to provide a home for this institute. In 1873, community member J. H. D. Henderson donated the hilltop land for the campus, overlooking the city. The University first opened in 1876 with the regents electing the first faculty and naming John Wesley Johnson as president. The first students registered on 16 October 1876. It would not be until 1877 that the first building would be completed; it would be later known as Deady Hall (for the first Board of Regents President and community leader Judge Matthew P. Deady.) The University of Oregon has been a leader in diversity since its very beginning; its inaugural class included two Japanese students.